Now in effect: Three drugs added to the Most Cost-Effective Setting Program

October 1, 2020

Independence seeks to ensure that our members receive injectable/infusion therapy drugs in a setting that is both safe and cost-effective. Since 2012, Independence has been reviewing the most appropriate setting for commercial members to receive certain injectable and infusion therapy drugs eligible for coverage under the medical benefit.

As of October 1, 2020, the following drugs were added to our Most Cost-Effective Setting Program:

  • Nyvepria™ (pegfilgrastim-apgf)
  • Phesgo™ (pertuzumab/trastuzumab/hyaluronidase-zzxf)‎
  • Uplizna™ (inebilizumab-cdon)

New requests for these drugs will require review for setting, as well as medical necessity, during the precertification process. Members who have precertification approval to receive these drugs in a hospital outpatient facility may continue treatment in this setting until their current precertification approval expires. At the next precertification review, Independence will evaluate the requested setting and make a coverage determination.


Visit our Most Cost-Effective Setting Program webpage for more information, including a downloadable list of all 74 drugs on the program.