Effective August 1, 2017, our policies on presumptive and 
definitive drug testing in substance abuse and pain management treatments will 
be updated. Key changes are detailed below.
Specimen validity/adulteration testing  
Most basic urine immunoassays have specimen validity checks built into the 
screening process and allow for a basic determination of potential urine sample 
tampering (e.g., dilution, substituted specimen, etc.). Most pain management 
laboratories have specimen validity testing protocols; however, these are 
deemed quality control measures. Specimen validity/adulteration testing is 
not eligible for separate reimbursement when performed in 
conjunction with presumptive and definitive drug testing, as this is considered 
part of the laboratory quality control practices.
The following CPT
® procedure codes, which represent specimen 
validity/adulteration testing, are being added to the policies and will not be 
separately reimbursed on or after August 1, 2017:
- 82542:  Column chromatography, 
includes mass spectrometry, if performed (e.g., HPLC, LC, LC/MS, LC/MS-MS, GC, 
GC/MS-MS, GC/MS, HPLC/MS), non-drug analyte(s) not elsewhere specified, 
qualitative or quantitative, each specimen
- 82570:  Creatinine; other 
source
- 83986:  pH; body fluid, not 
otherwise specified
- 84311:  Spectrophotometry, 
analyte not elsewhere specified
- 84315:  Specific gravity (except 
urine)
Hair and oral drug testing 
For pain management and substance abuse treatments, hair drug testing and 
oral fluid drug testing are considered 
experimental/investigational and, therefore, not covered because their 
safety and/or effectiveness cannot be established by review of the available 
published peer-reviewed literature.
 
Additional codes  
The following codes will be added to the list of Definitive Drug Class 
Testing codes as outlined within the Coding section of the policies:
 
- 80323:   Alkaloids, not 
otherwise specified
- 80327:   Anabolic steroids; 1 or 
2
- 80328:   Anabolic steroids; 3 or 
more
- 80329:   Analgesics, non-opioid; 
1 or2
- 80330:   Analgesics, non-opioid; 
3-5
- 80331:   Analgesics, non-opioid; 
6 or more
- 80368:   Sedative hypnotics 
(non-benzodiazepines)
- 80369:   Skeletal muscle 
relaxants; 1 or 2
- 80370:   Skeletal muscle 
relaxants; 3 or more
- 80372:   Tapentadol
- 80373:   Tramadol
Note: The codes above are included in the coverage limit of up to a 
maximum of 120 
presumptive and/or definitive drug tests in a calendar year when the policy 
criteria are met.
 
For more information, please refer to the following policies, which are 
currently posted as Notifications and will go into effect August 1, 
2017.
- Commercial: #06.02.44c: 
Presumptive and Definitive Drug Testing in Substance Abuse and Pain Management 
Treatments
- Medicare Advantage: #MA06.025c: 
Presumptive and Definitive Drug Testing in Substance Abuse and Pain Management 
Treatments
To view Notifications for these policies, visit our Medical Policy Portal and select Accept and Go to 
Medical Policy Online. Then select either Commercial or 
Medicare Advantage under Active Notifications.
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